Inter-patient variability in radiotherapy response
Phenotypic and genotypic predictive assays
Focus on RADIOGENOMICS, study of genetic differences in response to RT in
particular
single nucleotide polymorphisms
(SNPs) in selected
candidate
genes
(SNP: an inter-individual variation in the DNA sequence that involves the
substitution of a single nucleotide that occurs in more than 1% of the
population
Candidate gene: a gene whose function indicates that it could be mechanistically
involved in a specific process, such as radiation-damage repair or remodelling)