Diapositive 1

1497 / 1674

N =361 patients (1991-1998); age 45–75 years
pT1pN0M0; GI-II; ER+
Median follow-up of 5.9 years
2x2 clinical trial of factorial design:
• +/- radiotherapy &
• +/- tamoxifen (2 years)
Less local treatment: where is the limit?
Winzer K-J, et al. Eur J Cancer. 2004;40:998–1005.