531 / 1674
Study
N F/U
yrs
Med
Age
Med
Size
(cm)
Grade Margin
Width
In-Breast
Recurrence (%)
5-yr 12 yr
Surgery alone
ECOG
5194
≤2.5 cm, ≥3
mm margin
565 6.2 60 0.6 G I
G II
3 mm
6.1%
10.5%
14.4%
<1cm, , ≥3
mm margin
105 6.7 59 0.5 G III
15.3%
18%
APBI
According to
ECOG 5194
low-risk
65 3 60 < 2.5
I/II
NA
2%
APBI
according to
ECOG 5194
High-risk
10 3 60 < 1
III
NA
0%
Goyal 2010, Shah 2012, White 2013
Overall 5-y LR
1.4%
(99 pts)
Hughes J et al, JCO 2009; Solin LJ et al, JCO 2015