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RTOG 9804: a prospective randomized trial for
good-risk ductal carcinoma in situ comparing
radiotherapy with observation
(Mc Cormick B et al, JCO 2015)
•
At 7.2 years, risk of IBTR was 6.7% in the observation
arm compared to 0.9% in WBI arm
•
Selection criteria:
Screen-detected DCIS
Low to intermediate nuclear grade
≤ 2.5 cm size
margins negative at ≥ 3 mm