67 / 1674
Predictive biomarkers
Negative predictive value
(<5% chance to respond to
anti-estrogens or trastuzumab)
HIGH 95%
Positive predictive value
30-50%
ER/PGR
HR cut-off
• 10% in France
• 1-9%= 1.4% BC
•
1% ASCO
HER2
HER2 cut-off
•
> 10%, ratio ≥2
• ASCO 2013 /
GEFPICS 2014
• Increase of 2+ category