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Virus Characterization
“Genomic sequencing and limited study of
Variola
virus
surface proteins derived from geographically
dispersed specimens is an essential foundation for
important future work. Such research could be
carried out now, and could require a delay in the
destruction of known stocks, but would not
necessitate their indefinite retention.*”
* Assessment of Future Scientific Needs for Live
Variola Virus
; N.A.Press (1999)
Maximum Likelihood Analysis of Single
Nucleotide Matrices (
Variola virus
)
NON-
WEST
48
isolates passaged
2-3 times to
high titer master
d
African
minor
AND
AFRICA
BANGLADESH
NEPAL
INDIA
SUMATRA
MIDDLE
EAST
see
stocks
DNA extracted
Sequenced using
primer walking
methodology
Asian
Variola
major
African
major
EAST ASIA
ORIENT
W AFRICA
BRAZIL
Li Y.
et.al. PNAS 2007;104:15787-15792 Esposito et. al Science 2006
Alastrim minor