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LINKING DVH PARAMETERS TO CLINICAL

OUTCOME for TARGET/TUMOUR

1

Probability of local control

0 10 20 30

50 40

90 100

70 60

80

110 120 130 140

0

0.1

0.2

0.3

0.5

0.4

0.9

0.7

0.6

0.8

D90 (HR CTV)

Entire population (n=141)

Tumours > 5cm (n=76)

Dimopoulos et al. IJROBP 2009, Strahlentherapie 2009

141 patients

FIGO: IB-IVA, median

follow-up:

51 months

D90 for the HR-CTV and

probability of local control

20% less D90 per fraction ~ 10 Gy less for total dose