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Program name
Lead
organization
Design
Histology
Indication
# Expected to
accrue
Primary
outcome
measure(s)
Clinicaltrials.gov
identifier
GEMM
Yale University R
Advanced non-
V600–mutated
metastatic
melanoma
Metastatic
96
BORR
NCT02094872
ISPY-2
Quantum Leap
Healthcare
Collaborative
A–R
Locally
advanced breast
cancer
Neo-Adjuvant 800
pCR
NCT01042379
LUNG-MAP
SWOG and NCTN R
Squamous
Metastatic
10,000
(screening)
PFS
NCT02154490
SAFIR-02 breast UNICANCER R
Metastatic non-
HER2
+
breast
cancer
Metastatic
400 (screening)
210
(randomized)
PFS
NCT02299999
SAFIR-02 lung UNICANCER R
NSCLC
Metastatic
650 (screening)
+ 220
(treatment)
PFS
NCT02117167
Umbrella trials matching patients to therapies
based on molecular profiles