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Basket trials matching patients to therapies
based on molecular profiles
Program
name
Lead
organizatio
n
Design Histology Indication
# Expected
to accrue
Primary
outcome
measure(s)
Clinicaltrial
s.gov
identifier
CREATE EORTC NR
ALK/MET
activated
advanced
solid
tumors
Metastatic 582
ORR
NCT015249
26
IMPACT II
MD
Anderson
R
Advanced
solid
tumors
Metastatic 1,362
PFS
NCT021522
54
My
Pathway
Genentech NR
Advanced
solid
tumors
Metastatic 500
ORR
NCT020911
41
SHIVA
Institut
Curie
R
Advanced
solid
tumors
Metastatic 1,000
PFS
NCT017714
58