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Takahashi T. et al. Lancet Oncol 2017
Brain mets @ 12 months:
58% vs 32.4%
Study early terminated because of futility after 1
st
interim analysis
PCI did not result in longer OS compared with observation in patients with any response to
initial chemotherapy and a confirmed absence of brain metastases when patients receive
periodic MRI examination during follow-up.
OS @ 12 months:
11.6% vs 13.7%
Japanese trial: futility of PCI when mets are excluded by MRI