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Socinski M. and Bogart J, JCO 2007;25

Paradigm shifts in the management of SCLC:

significant contribution from RT

ED-SCLC:

LD-SCLC

Study

Regimen

Impact on Survival

Slotman et al.

(NEJM 2007)

Prophylactic cranial irradiation

+13.8% at 1 year

Slotman et al.

(Lancet 2015)

CT + PCI vs CT+ PCI + Thoracic RT +5% at 1 year