1314 / 1851
TRIAL
No
Median FU Primary endpoint Secondary endpoints
ACT 1
(UKCCR
1996)
585 42 months Local treatment failure
(composite of local
failure and colostomy)
Overall survival
EORTC 22861
(Bartelink 1997)
110 42 months Local failure
Event-free survival
RTOG 87-04/ECOG
(Flam 1996)
291 3 years
Disease‐free survival.
Overall survival
Colostomy-free survival,
Loco-regional control etc..
RTOG 98-11
(Ajani 2008)
644 2.51 years Disease‐free survival.
Overall Survival
Cumulative incidence of
Colostomy
ACCORD-03
(Conroy 2009)
307 43 months Colostomy-free
survival
Overall survival
Cancer-specific survival
Local control etc..
ACT II
(CRUK)
(James 2013)
940 61 months
Complete response
Acute Toxicity
Recurrence-free
survival
Overall survival
Cancer-specific survival
Colostomy rate