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Definition of composite disease-related
endpoints used in Anal Cancer Trials
Trial
Endpoint Loco-
regional
disease
Pelvic
disease
Distant
mets
Death New
tumour
Colostomy
ACT I
1
Local
Treatment
Failure
ACT II
6
Progression
-Free
Survival*
EORTC
7
Event-Free
Survival
ACCORD
03
5
Event-Free
Survival
RTOG
8704
8
Disease-
Free
Survival
RTOG
9811
4
Disease-
Free
Survival