1365 / 1851
Primary tumour
Surgery
to recurrence is straightforward –tumour
is removed - so definitely no tumour and first new
evidence is event
Chemoradiation (CRT)
•
Tumour disappears at some point
•
Some never free from disease –so treatment
failure - assume event occurs at randomisation
•
Some disappears and then reappears
ie both an early and late pattern to loco-regional