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Regarding the HD12 trial:
Amongst the patients with bulk
PFS in favor of RT arm
@ 10 years (88.6% vs 83.5%), HR 1.47
OS marginally in favor of RT arm
@ 10 years (93% vs 90.2%)
Amongst the patients with residual disease
PFS in favor of RT arm
@ 10 years (89.3% vs 83.4%)
OS in favor of RT arm
@ 10 years (94.4% vs 88.4%)
No significant difference in terms of second cancer @ 10 years (9.7% vs 6.4%)