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Kinases are involved in processes leading to cell
proliferation and survival
Kinases are popular targets
- virtually every signal transduction process
is wired through phosphotransfer cascade
-
despite high degree of conservation highly specific
agents can be developed
-
inhibition of kinase in normal tissue can often be
tolerated (therapeutic window)
-
to date approx. 80 inhibitors advanced to some stage
of clincial evaluation
Kinases in Oncology