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In the ‘oncogenic shock’ model,
addictive oncoproteins (e.g. RTKs, red
triangle)
trigger at the same time pro-
survival and pro-apoptotic signals
(top,
red and blue pathway, respectively).
Under normal conditions, the pro-
survival outputs dominate over the
pro-apoptotic ones (top), but
following
blockade of the addictive receptor
, the
rapid decline in the activity of survival
pathways (dashed lines, bottom)
subverts this balance in favour of
death-inducing signals, which tend to
last longer
and eventually lead to
apoptotic death.
Oncogene Addiction: 2 models
b) oncogenic shock model