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Oncogene Addiction: 2 models
a) genetic streamlining theory
The ‘genetic streamlining’ theory
postulates that non-essential
pathways (top, light grey) are
inactivated during tumour
evolution, so that dominant,
addictive pathways (red) are not
surrogated by compensatory
signals. Upon abrogation of
dominant signals, there is a
collapse in cellular fitness and
cells experience cell-cycle arrest
or apoptosis (bottom, red to
yellow shading).
Torti and Trusolino, 2011