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CMS4 stemlike

Del Rio M, et al. Molecular subtypes of metastatic

colorectal cancer are associated with patient

response to irinotecan-based therapies. Eur J

Cancer. 2017 May;76:68-75

87% response to FOLFIRI in CMS4

Song N, et al. Clinical Outcome From Oxaliplatin

Treatment in Stage II/III Colon Cancer According

to Intrinsic Subtypes: Secondary Analysis of

NSABP C-07/NRG Oncology Randomized Clinical

Trial. JAMA Oncol. 2016 Sep 1;2(9):1162-9

Lack of benefit from Oxaliplatin/poor prognosis in CMS4