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Primary end-point [n=515]
R0 resection rates (surgery performed & pathologic R0 status):
77% for SCPRT with 3 cycles of chemotherapy
71% for CRT (control arm)
(p=0.081)
Secondary end-points
SCRTx +
FOLFOX4
CRTx
P value
Overall acute
toxicity
75%
83% p= 0.006
Grade III/IV
toxicities
23%
21%
NS
pCR rate
16%
12%
p= 0.17