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Conclusions

1. 5FU-based CRT more effective

(downsizing) than RT but no improvement

in SpS, DFS or OS

2. SCPRT = CRT in resectable cancer

3. Radio-sensitizing 5FU-based CRT with sub

therapeutic oxaliplatin ?

4. But minimal benefit for T3N0 on mets

5. Biologicals have not yet delivered

6. Immunotherapy is coming