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FFCD 9901 trial
Surgery alone versus chemoradiotherapy followed by surgery
for localized esophageal cancer :
Early stages
: Stage I&II (T1-T1, N0-1, T3N0)
cN1: #25%; cT3: #18%
5FU-CDDP/ RT: 45 Gy
RT-CT Surg alone
Nbre pts
98
97
Post-op Mortality (%)
11.1
3.4
0.049
5-yr survival (%)
41.1
33.8
NS
Local recurrences (%)
22.1
28.9
0.02
R0 resection (%)
93.8
92.1
Per-op. RT-CT is not useful for early stages
Mariette, J Clin Oncol, 32:2416-2422, 2014