261 / 1851
Pre-operative CT or RT-CT?
Swedish randomized trial
3 cycles of Cisplatin/5FU
±
Radiotherapy: 40 Gy
CT RT-CT
N pts
91
90
90-day mortality (%)
3 8 0.12
Post-op complications (%) 35 38 0.28
pCR (%)
9 28 0.002
R0 resection (%)
74 87 0.042
pN1
62 35 0.001
Klevebro, Ann Oncol, 2016, 27: 660-667
Overall survival
On Going trials:
- Irish neo-AGIS: MAGIC vs CROSS
- Japan