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Predictive factors of chemo-
radiosensitivity
• Apoptosis: p53, p21, Survivin, bcl2
• Tumour proliferation: NF-
k
B, COX-2, cyclins
• EGFR, HER-2
• DNA repair: ERCC1
•Tumour hypoxia
• Thymydylate synthase (5FU)
• Metallothionein, GST-
P
, P-glycoprotein (cisplatin)
• Gene expression arrays
• SNPs for AKT, PTEN, …