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Secondary and Downstream Mutations
Sensitivity to Gefitinib Differs Among NSCLC Cell Lines Containing Various
Mutations in
EGFR
or
KRAS
The three indicated NSCLC cell lines, H3255 (L858R mutation), H1975 (both T790M
and L858R mutations), and H2030 (wild-type
EGFR,
mutant
KRAS
), were grown in
increasing concentrations of gefitinib, and the density of live cells after 48 h of
treatment was measured
Kobayashi, PLoS Med, 2, e73