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Molecular evolution of resistance to treatment:
acquired during therapy?
Already present in a clonal subpopulation within the
tumours
prior
to the initiation of therapy?
Is resistance is therefore a fait accompli—the time to recurrence
is simply the interval required for the subclone to repopulate the
lesion.?
Is the short time interval of recurrence due to the rapid
expansion of the resistant subclone immediately following
treatment initiation?
Required:
Combination therapies targeting at least two different pathways -
processes.
Relevant Questions: