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Hypoxia-classification: 15-gene hypoxia classifier
• Based on hypoxia induced genes (in vitro/in vivo validated)
• Classification based on gene expression similarity to either
”more” or ”less” hypoxic tumours as estimated with pO2-
electrode in an independent trainingset of 58 H&N cancer
patients
Head and neck tumours (n=58)
0 5 10 15 20 25 30 35 40 45 50 55
Hypoxic fraction (%)
0
20
40
60
80
100 pO 2 -measurements < 2,5 mmHg
More
Hypoxic
Less
Hypoxic
Toustrup K et al, 2011