464 / 1851
414 patients enrolled in
the DAHANCA 5 trial
219 randomly assigned to
radiotherapy and nimorazole
195 randomly assigned to
radiotherapy and placebo
52 excluded from
classification
(2 failed in PCR,
50 did not
have tumour tissue for
PCR)
39 excluded from
classification
(1 failed in PCR,
38 did not
have tumour tissue for
PCR)
Nimorazole group:
167 for classification
Placebo group:
156 for classification
Validating the hypoxia classifier: Independent dataset
”More” hypoxic
”Less” hypoxic
Nimorazole group:
167 for classification
Placebo group:
156 for classification
323 tumour samples for classification
Classification
(114)
(209)
s” hypoxic (209)
Toustrup K et al, 2012