800 / 1851
MMC - Comparison 1 versus 2 doses
no difference
•
PFS (HR 0.85, 95% CI 0.37–1.92),
•
CFS (HR 0.91, 95% CI 0.31–2.67) between the MMC1 and
MMC2 groups.
•
Acute grade
⩾
2 toxicities were worse in the MMC2 group.
•
3 treatment-related deaths, all in the MMC2 group
•
White et al Chemoradiotherapy for squamous cell carcinoma of the
anal canal: Comparison of one versus two cycles mitomycin-C.
Radiother Oncol 2015;117 (2):240–245