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ADXS11-001 immunotherapy
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live attenuated Listeria monocytogenes (Lm)
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bioengineered to secrete a HPV-16-E7 fusion protein
targeting HPV transformed cells.
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Anal cancer cells infected with HPV have the tumour
associated antigen HPV E7.
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So ADXS11-001 causes antigen presenting cells to be
stimulated to facilitate immune cells to attach to cancer
cells expressing HPV E7