820 / 1851
PLATO – PERSONALISING RADIOTHERAPY DOSE FOR
ANAL CANCER
53.2Gy
28F
58.8Gy
28F
61.6Gy
28F
Stratify for Cape vs. 5-FU
50.4Gy
28F
41.4Gy
23F
ACT3
ACT4
Local excision
Obs
Adverse
Standard
Ph II
Ph III
Pilot
T1,T2<4cm N0
T3/4 NO
T2N2, T3/4 N1-3
41.4Gy
23F
T1 N0
Anal margin
Phase II trial
Phase II/III trial
Courtesy of David Sebag-Montefiore