Diapositive 1

832 / 1851

LGG: classical prognostic factors
Variable HR p value
 Age ≥40 vs <40 y 1.26 0.0077
 Pre-surgical
Neurologic deficit
Yes vs No 1.35 0.0013
 Largest diameter ≥6 cm vs <6 cm 1.39 0.0003
 Histology subtype Astro vs Oligo 1.30 0.0050
 Tumor crossing
the midline
Yes vs No 1.37 0.0005
Pignatti F. et al. JCO 2002;20
Gorlia T. et al. Neuro-Oncol 2013;15
Prognostic factors for OS: multivariate model
Variable HR p value
 Neurologic deficit Worse baseline
neurologic status
1.5 <0.0001
 Largest diameter <5 cm vs ≥5 cm 1.7 <0.0001
 Histology subtype Astro vs Oligo 1.9 <0.0001
 Shorter time since
first symptoms
>30 weeks vs
<30 weeks
0.67
(only EORTC)
0.009
Prognostic factors for OS: multivariate model