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Interplay - Dynamic IMRT

If motion mitigation is not

applied during IMRT to a

moving target

CTV under/over-dosage

Delivery time comparable to

breathing period

Segment size comparable to

breathing amplitude

Fractionation

1fx

20% dose variation

30fx

<2% dose variation

Bortfeld PMB (47) 2002 - Jiang PMB (48) 2003 - …

Multiple fields

statistical averaging over

the beam reduces the overall dose error

Avoid low MU segments (few s delivery)

Seco et al. Med Phys(34) 2007

Bortfeld PMB (47) 2002