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Relative Uncertainty in the SOBP:
Variation of the RBE as a function of various parameters
(depth, dose, beam energy, fractionation, tumor type, etc.)
Precision
probably around 10%
Absolute uncertainty:
Absolute value of the RBE, which determines the applied
biological effective dose
Accuracy
of RBE(C12) probably around 20% - 30%
Comparison:
Clinical Proton-RBE: ~10-20%
RBE for Brachytherapy (
125
I and
103
Pd): ~1.5 (+-20%)
Changes of fractionation schemes (using
a/b
): ~15%
The Uncertainty of RBE (by Oliver Jakel - HIT)
“Correct doses” have to be evaluated in clinical
studies