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GEC-ESTRO APBI interstitial
brachytherapy RCT
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Phase III RCT involving 16 European centres
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1184 patients with low risk invasive or DCIS
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randomised to whole breast or APBI using interstitial multi-
catheter techniques delivered in 4-5 days post-op
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5 year local recurrence rates
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APBI 1.44% (95% CI 0.51-2.38)
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Whole breast 0.92% (95% CI 0.12-1.73)
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No significant difference in 5 year late toxicity
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Brachytherapy non-inferior to whole breast EBRT
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Strnad V et al. Lancet 2016:387 (10015):229-38.