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Deterministic effects → Tissue reactions (ICRP 2007 – 2012)
•
ICRP 60 – 1991
→
Deterministic: casually determined by preceding events.
•
ICRP 103 - 2007
→
They are not necessarly PREdetermined and can be modified after
irradiation by the use of various biological response modifier. Stochastic are presumed to be
unicellular in origin while
Tissue /Organ reactions
are due to injury in a population of cells.
•
ICRP 60 – 1991
→
the emphasis was on radiation-induced cell killing in relation to tissue
damage.
•
ICRP 118 - 2012
→
1) the cytotoxic effects of radiation cannot explain all tissue reactions
(especially late effects - fibrosis); 2) non-lethal effects of radiation on cells and tissues, with the
resultant disturbances in molecular cell signalling, also play a crucial role in determining tissue
response to radiation; 3) more information has become available regarding the effect of
biological response modifiers in mitigating tissue reactions, which has the effect of modifying
threshold doses.