Microsoft PowerPoint - Physics Bucharest



Prostate

: increased risk relative to surgery, for



10 y fu: bladder (ERR=77%), rectum

(105%), in-field sarcomas (217%), and lung (42%)

(Brenner et al. 2000)



Breast

: compared to no RT: contralateral breast (ERR=18%), soft-tissue sarcoma

(134%), lung (61%), oesophagus (106%), leukemia (71%)

(EBCTCG, Lancet 2005)



Breast

: compared to no RT: ERR= 45% for sites with D>1Gy (lung, oesophagus,

pleura, bone, soft tissue), ERR=9% for contralateral breast ca (D≈1Gy), no evidence for

enhanced risk for D<1 Gy

(Berrington de Gonzalez et al. 2010)



Cervix

: compared to general population: for all latency periods ERR(D>3Gy) >

ERR(1Gy<D<3Gy) > ERR(D<1Gy). 10-19y: 53%, 22%, 12%

(Chaturvedi, Travis, et al, 2007)



Several sites

: 85%: D



3 Gy

(Dörr and Herrmann, 2002)

Various primary tumors:

Relatively few secondary solid cancers for very low doses

Clinical data

Position of RT induced 2

tumors relative to HIGH

DOSE AREA