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Oncogenes (Tumor Inducing Genes)
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Proto-oncogen
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normal gen
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aid in the differentiation and growth regulation in cells
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Oncogenic mutation
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Mutation in a proto-oncogene resulting in an oncogene
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Types of mutations
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Insertions
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deletions
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point mutations
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gene amplification or duplication (extra copies)
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chromosomal translocation (a section of one chromosome is detach and
reattach itself to another chromosome)
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How does a mutation activate an oncogene?
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Increased enzyme or protein activity
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Regulation loss
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Increased protein concentration
Increased transcription rate