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Classification of effects on the tumor

Uniform criteria for reporting

response

,

recurrence, disease-free

interval, and toxicity were proposed in 1979 after a meeting on the

Standardization of Reporting Results of Cancer Treatment

and were

subsequently widely accepted.

These

response

criteria, known as the

World Health Organization

(WHO) criteria

, are based largely on tumor measurements in two

dimensions (the longest perpendicular diameters in the axial plane).

WHO: WHO Handbook for Reporting Results of Cancer Treatment. Geneva, Switzerland, World Health Organization,

WHO offset

publication 48, 1979

Miller AB, Hoogstraten B, Staquet M, et al: Reporting results of cancer treatment.

Cancer 47:207-214, 1981