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Organs at risk (OAR)-serial-parallel organisation
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Serial-parallel organisation-Functional Subunit Concept
Most organs are not clearly serial-like or
parallel-like structure,
Examples- Heart (myocardium- parallel,
coronary arteries –serial); Kidney
(glomerulus- parallel, tubules-serial)
Report at least three dose – volume
specifications
Include D
mean
, D
2 %,
and, V
D
(which if
exceeded has high probability of serious
complication)
For tubular types of organ (e.g., the rectum), delineation of
the wall is preferred to whole-organ delineation.
Emami B et al.,Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys 1991,
21(1):109-122. Bentzen SM, et al., Quantitative Analyses of Normal Tissue Effects in the Clinic (QUANTEC):
an introduction to the scientific issues. Int J Radiat Oncol Biol Phys 2010, 76(3 Suppl):S3-9.