552 / 1542
75.6 Gy
< 72 Gy
81 Gy IMRT
Zelefsky IJROBP 2008
Late Grade ≥2 rectal toxicities
1751 pts
Scientific evidence:
No RCT; many comparative studies
Consistent results with :
↓ acute and late GI toxicity
=/↓ acute and = late GU toxicity
↑ biochemical control with dose-escalation
32
Prostate cancer
Evidence