548 / 1542
Head & Neck cancer
Study
Organ
IMRT/
non-MRT
Primary endpoint
Other endpoints
IMRT Non-
IMRT
p
Nutting 2011
(PARSPORT)
oropharynx
hypopharynx
47/47
Xerostomia ≥2 (2y)
Acute fatigue
2y OS
29%
74%
78%
83%
41%
76%
<0,001
0,002
NS
Kam 2007
nasopharynx
28/28
Xerostomia ≥2 (1y)
39% 82% 0,001
Gupta 2012
Rathod 2013
oropharynx
hypopharynx
larynx
32/28
Acute xerostomia ≥2
Xerostomia ≥2 (2y)
SC fibrosis (2y)
3y OS
QOL
59%
23%
14%
71%
better
89%
59%
56%
68%
0,003
0,02
0,005
NS
<0,05
Pow 2006
nasopharynx
46/50 Saliva flow
QOL
better
better
0,002
<0,001
28
Scientific evidence: 4 RCT
(& comparative case studies)
Evidence