546 / 1542
Improved dose distribution
→
clinical benefit?
Review 2012 on
IMRT vs. non-IMRT
:
61 comparative studies;
only 6 RCT
Primary endpoints: acute and late toxicity
Not powered to detect differences in tumor control
26
Staffurth Clin Oncol 2010
De Neve Semin Radiat Oncol 2012
Clinical use of IMRT: What’s the evidence?
3 RCT in
LA-H&N
(205 pts),
3 RCT in
breast cancer
(1809 pts)
Evidence