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Relative Biological Effectiveness (RBE) - particles

RBE-weighted Dose (Gy (RBE)) = Absorbed Dose (Gy) x RBE

RBE =

D

(Co-60; 250kV)

D

(p-ions)

Biological effect

(cell inactivation)

RBE is the ratio of the dose of photons, e.g.,

60

Co-rays or linear accelerator X-

rays, relative to that of protons/ions required to produce a defined biologic

response

RBE is a function of LET, Z, cell type, dose, endpoint