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5 Options for chemotherapy
in locally advanced rectal cancer
•
Induction
- pre RT (Short-course(SCPRT) or
chemoradiation (CRT)(
Expert, Expert C,
Fernandez-Martos, Contre
)
•
Concurrent
- With RT (CRT) (but NB toxicity)
(5 oxaliplatin trials,1 irinotecan trial)
•
Consolidation
- post CRT or SCPRT if waiting 6
12 weeks before surgery
(Garcia-Aguilar, Polish ,
RAPIDO –Nordic Countries/Holland)
•
NACT alone Without radiation
(Prospect,
Bacchus
)
•