Microsoft PowerPoint - L00 Introduction

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Mid eighties first phase III trials
Arm A Arm B
US (RTOG 8704) XRT+ 5 FU XRT + 5 FU-Mito C
EORTC 22861 XRT XRT + 5 FU-Mito C
UKCCCR ACT I XRT XRT + 5 FU-Mito C
US (RTOG-8704)
XRT+ 5 FU XRT + 5 FU-MMC p value
Complete response 86% 92,2%
Colostomy- free survival 59% 71% 0,014
Colostomy rate 22% 9% 0,002
DFS 51% 73%
OS 71% 78,1% 0,31