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Page 9
Oliver Jäkel
Medical Physics
He:
▲
,
12
C:
●
,
20
Ne:
▼
Weyrather Int. J. Rad. Biol. (1999),
Furusawa Rad. Res. (2000)
The clinical relevance of has not been shown yet.
• Increased RBE for high LET in resistant tumors.
• Improved outcome for high LET in hypoxic tumors.
• Benefit for Carbon as compared to protons
C
O
Dependence of RBE and OER on LET
p
C
Page 10
Oliver Jäkel
Medical Physics
Stokkevåg et al.
Acta Oncol
2014
Proton RT for Medulloblastoma treatments
Finite range of protons reduces dose to dose reduction in heart,
lung, intestine, mediastinum