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Chen W, Unkelbach J, Trofimov A, Madden T, Kooy H, Bortfeld T, Craft D. Including 

robustness in multi‐criteria optimization for intensity‐modulated proton therapy. Phys Med 

Biol. 2012 Feb 7;57(3):591‐608. 

Fredriksson A, Forsgren A, Hårdemark B. Minimax optimization for handling range and setup 

uncertainties in proton therapy. Med Phys. 2011 Mar;38(3):1672‐84.  

Fredriksson A. A characterization of robust radiation therapy treatment planning methods‐

from expected value to worst case optimization. Med Phys. 2012 Aug;39(8):5169‐81.  

Fredriksson A, Forsgren A, Hårdemark B. Maximizing the probability of satisfying the clinical 

goals in radiation therapy treatment planning under setup uncertainty. Med Phys. 2015 

Jul;42(7):3992.  

Fredriksson A, Bokrantz R. A critical evaluation of worst case optimization methods for 

robust intensity‐modulated proton therapy planning. Med Phys. 2014 Aug;41(8) 

Fredriksson A, Bokrantz R. The scenario‐based generalization of radiation therapy margins. 

Phys Med Biol. 2016 Mar 7;61(5):2067‐82. 

Bokrantz R, Fredriksson A. Scenario‐based radiation therapy margins for patient setup, 

organ motion, and particle range uncertainty. Phys Med Biol. 2017 Feb 21;62(4):1342‐1357 

Witte MG, van der Geer J, Schneider C, Lebesque JV, Alber M, van Herk M. IMRT  

optimization including random and systematic geometric errors based on the expectation of 

TCP and NTCP. Med Phys. 2007 Sep;34(9):3544‐55. 

Bohoslavsky R, Witte MG, Janssen TM, van Herk M. Probabilistic objective functions for 

margin‐less IMRT planning. Phys Med Biol. 2013 Jun 7;58(11):3563‐80.  

Fontanarosa D, van der Laan HP, Witte M, Shakirin G, Roelofs E, Langendijk JA, Lambin P, 

van Herk M. An in silico comparison between margin‐based and probabilistic target‐

planning approaches in head and neck cancer patients. Radiother Oncol. 2013 

Dec;109(3):430‐6.  

Witte M, Shakirin G, Houweling A, Peulen H, van Herk M. Dealing with geometric 

uncertainties in dose painting by numbers: introducing the ΔVH. Radiother Oncol. 2011 

Sep;100(3):402‐6.  

Fontanarosa D, Witte M, Meijer G, Shakirin G, Steenhuijsen J, Schuring D, van Herk M, 

Lambin P. Probabilistic evaluation of target dose deterioration in dose painting by numbers 

for stage II/III lung cancer. Pract Radiat Oncol. 2015 Jul‐Aug;5(4):e375‐82.