1302-1303 / 2605
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Phase I/II dose escalation trial 2004-2008
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Preoperative C-ion RT for resectable SCC
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Thirty-one patients with stages I–IVa
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Dose of CRT was escalated from 28.8 to 36.8 GyE in 8
fractions over 2 weeks
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Low toxicity: 1 patient: G3 respiratory distress
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5-year overall survival rates for stages I, II, and III were
61, 77, and 29 %, respectively
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5-year cause-specific survival: 71 %
Carbon ion therapy (NIRS)