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Aim 1: Insight into Biologic Mechanisms
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Specific Aim 1: To determine the early changes in multiple
biomarkers in patients undergoing RT, and how these changes differ
in proton versus photon therapy.
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Hypothesis: Early increases in circulating biomarkers will differ
according to RT; photon therapy will result in a more adverse
biomarker profile.
Biologic Alteration
Biomarker
Inflammation
GDF-15, hsCRP
Microvascular Dysfunction
PlGF
Oxidative Stress
MPO, PON, Aryl
Myocyte Injury
TnT
Myocyte Stress
NT-proBNP
Fibrosis
Galectin-3